The nation’s first cannabis cafe was set to open Tuesday in West Hollywood. Lowell Cafe, located at 1201 N. La Brea Avenue, says the opening is a major step in the normalization of recreational marijuana. The first cannabis cafe in the United States opens Tuesday in Los Angeles. Called Lowell Farms: A Cannabis Cafe, it will be the first farm-to-table restaurant that highlights cuisine and cannabis.West Hollywood created eight cannabis consumption licenses and of more than 300 applicants, Lowell Farms was granted the first one, the restaurant says.