The objective of this review is to critically examine the use of performance-enhancing substances in the field of bodybuilding and shed light on the resulting implications for public health. By analyzing the prevalence, effects, motivations, and risks associated with using these substances, this article aims to understand the complex relationship between bodybuilding and performance-enhancing substances thoroughly. Through a comprehensive synthesis of current research and literature, the objective is to contribute to the existing knowledge base and promote informed discussions among professionals, policymakers, and the general public regarding the potential health consequences and broader societal implications of performance-enhancing substance use in the context of bodybuilding.